Azide-PEG4-Tos

CAT: 0804-HY-140351-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-140351-01Size:100 mg

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Description

Azide-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG4-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

CAS Number

168640-82-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azide-peg4-tos.html

Purity

99.59

Solubility

10 mM in DMSO

Smiles

[N-]=[N+]=NCCOCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O

Molecular Formula

C15H23N3O6S

Molecular Weight

373.42

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Chemical Information

Azide-PEG4-Tos

CAS Number	168640-82-2
PubChem CID	59470485
IUPAC Name	2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
Molecular Formula	C15H23N3O6S
Molecular Weight	373.4
XLogP	2
Topological Polar Surface Area	93.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	14
Heavy Atom Count	25
Formal Charge	0
Complexity	482

SMILES

CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCN=[N+]=[N-]

InChI

InChI=1S/C15H23N3O6S/c1-14-2-4-15(5-3-14)25(19,20)24-13-12-23-11-10-22-9-8-21-7-6-17-18-16/h2-5H,6-13H2,1H3

InChIKey

ZYZZLMAEZYMGEU-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 168640-82-2

CID: 59470485

Formula: C15H23N3O6S

MW: 373.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	373.4
XLogP3	2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	14
Exact Mass	373.13075664
Monoisotopic Mass	373.13075664
Topological Polar Surface Area	93.8 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	482
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-140380	Tos-aminoxy-Boc-PEG4-Tos
HY-130417-01	Tos-PEG4-acid
HY-130387-01	Propargyl-PEG4-Tos
HY-W004816-01	Bis-Tos-PEG4
HY-130819-01	Tos-PEG4-THP
HY-130473-01	Tos-PEG4-CH2COOH
HY-114661-01	M-PEG4-Tos
HY-140353-01	Azide-PEG6-Tos
HY-W190738	Azide-PEG8-Tos
HY-140354-01	Azide-PEG7-Tos

Alternative Products

Catalog	Name
sc-496427	Azide-PEG4-Tos
MD038038-4-01	Tos-PEG4-Tos
sc-496216	PEG4-Tos
T17119-01	Tos-aminoxy-Boc-PEG4-Tos
GNC24863-01	Tos-PEG4-CH2CO2H
MD038067-4-01	Tos-PEG4-CH2CH2COOtBu
MBS5771473	Bis-Tos-PEG4
MBS5770107	Tos-PEG4-acid
MBS5769855	Propargyl-PEG4-Tos
GTR19215621-01	Tos-PEG4-THP

Azide-PEG4-Tos

Chemical Information

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