Parathyroid Hormone Recombinant Rabbit Monoclonal Antibody [JE66-58]

Parathyroid Hormone Recombinant Rabbit Monoclonal Antibody [JE66-58]

• Description: Parathyroid hormone (PTH), also called parathormone or parathyrin, is a peptide hormone secreted by the parathyroid glands that regulates the serum calcium concentration through its effects on bone, kidney, and intestine. PTH influences bone remodeling, which is an ongoing process in which bone tissue is alternately resorbed and rebuilt over time. PTH is secreted in response to low blood serum calcium (Ca2+) levels. PTH indirectly stimulates osteoclast activity within the bone matrix (osteon), in an effort to release more ionic calcium (Ca2+) into the blood to elevate a low serum calcium level. The bones act as a (metaphorical) "bank of calcium" from which the body can make "withdrawals" as needed to keep the amount of calcium in the blood at appropriate levels despite the ever-present challenges of metabolism, stress, and nutritional variations. PTH is "a key that unlocks the bank vault" to remove the calcium. PTH is secreted primarily by the chief cells of the parathyroid glands. The gene for PTH is located on chromosome 11. It is a polypeptide containing 84 amino acids, which is a prohormone. It has a molecular mass around 9500 Da. Its action is opposed by the hormone calcitonin. Disorders that yield too little or too much PTH, such as hypoparathyroidism, hyperparathyroidism, and paraneoplastic syndromes can cause bone disease, hypocalcemia, and hypercalcemia.
• Product Name Alternative: hPTH antibody Parathormone antibody Parathyrin antibody Parathyroid hormone 1 antibody Parathyroid hormone antibody Prepro PTH antibody Preproparathyroid hormone antibody PTH antibody PTH1 antibody PTH1 receptor antibody PTH1R antibody PTHR antibody PTHR1 antibody PTHY_HUMAN antibody
• Abbreviation: PTH
• CAS Number: 9000-83-3
• Swiss Prot: P01270 Human, P04089 Rat,
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Parathyroid Hormone aa 26-75 / 115.
• Isotype: IgG
• Clone: JE66-58
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: HEK-293 cell lysate, CAL-62 cell lysate, A549 cell lysate, Jurkat cell lysate, mouse thymus tissue lysate, rat thymus tissue lysate, human parathyroid tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1;1,000 ;IHC-P: 1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 13 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes