Thyroid Hormone Receptor alpha Recombinant Rabbit Monoclonal Antibody [JE40-49]

Thyroid Hormone Receptor alpha Recombinant Rabbit Monoclonal Antibody [JE40-49]

• Description: Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor protein that in humans is encoded by the THRA gene. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Mutations of the THRA gene may cause nongoitrous congenital hypothyroidism-6, a subtype of congenital hypothyroidism.
• Product Name Alternative: AR7 antibody c-erbA-1 antibody C-erbA-alpha antibody CHNG6 antibody EAR-7 antibody EAR7 antibody ERB-T-1 antibody ERBA antibody ERBA-related 7 antibody ERBA1 antibody NR1A1 antibody Nuclear receptor subfamily 1 group A member 1 antibody THA_HUMAN antibody THRA antibody THRA1 antibody THRA2 antibody Thyroid hormone receptor alpha antibody thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) antibody thyroid normone nuclear receptor alpha variant 1 antibody triiodothyronine receptor antibody V-erbA-related protein 7 antibody
• Abbreviation: THRA, EAR7, ERBA1, NR1A1, THRA1, THRA2
• CAS Number: 9000-83-3
• Swiss Prot: P10827 Human
• Cellular Locus: Nucleus; Cytoplasm, Nucleus.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human Thyroid Hormone Receptor alpha aa 416-465 / 490.
• Isotype: IgG
• Clone: JE40-49
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB
• Positive Control: A431 cell lysate, SW480 cell lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 55 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes