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Antiproliferative agent-60

CAT: 0804-HY-168113Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168113Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antiproliferative agent-60 (compound 8c) is a 11-Azaartemisinin derivative with superior anticancer activities. Antiproliferative agent-60 shows IC50 values of 7.7 μM, 42.5 μM, and 15.5 μM for epidermoid carcinoma (KB), HepG2, and A549 cells, respectively. Antiproliferative agent-60 exhibits significant tumor selectivity, up to 32-fold higher compared to Hek293 normal cells[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antiproliferative-agent-60.html
Smiles
BrC1=CC=CC(N2C=C(CN3[C@H]4[C@]56C(CC[C@@H](C)C5CC[C@](OO6)(C)O4)[C@@H](C)C3=O)N=N2)=C1
Molecular Formula
C24H29BrN4O4
Molecular Weight
517.42
References & Citations
[1]Dung Tien Nguyen, et al. 11-Azaartemisinin derivatives bearing halogenated aromatic moieties: Potent anticancer agents with high tumor selectivity. Bioorg Med Chem Lett. 2024 Sep 18:113:129969.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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