EM12-FS

• Description:

  EM12-FS is a cereblon (CRBN) ligand that binds CRBN at His353 and a molecular glue degrader of NTAQ1. EM12-FS has a human plasma half-life of 196 min[1].

• UNSPSC:

  12352005

• Target:

  Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/em12-fs.html

• Purity:

  98.4

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1NC(C(CC1)N2C(C3=CC(OS(=O)(F)=O)=CC=C3C2)=O)=O

• Molecular Formula:

  C13H11FN2O6S

• Molecular Weight:

  342.30

• References & Citations:

  [1]Cruite JT, et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem Biol. 2022 Jul 8;3 (9) :1105-1110.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2839138-44-0]