FS-694

• Description:

  FS-694, a chemical probe, is the inhibitor for p38α with an IC50 of 0.2 nM. FS-694 inhibits the TNFα release in human whole blood with an IC50 of 35.0 nM[1].

• UNSPSC:

  12352005

• Target:

  P38 MAPK

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  FC(C=C1)=C(NC(C2=CC=CC=C2)=O)C=C1NC3=CC(CCC(C=CC(C(NCCN4CCOCC4)=O)=C5)=C5C6=O)=C6C=C3

• Molecular Formula:

  C35H33FN4O4

• Molecular Weight:

  592.66

• References & Citations:

  [1]Walter NM, et al., Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine. J Med Chem. 2017 Oct 12;60 (19) :8027-8054.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1417404-27-3]