FS-694

CAT: 0804-HY-172195Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172195Size:1 Each
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Description
FS-694, a chemical probe, is the inhibitor for p38α with an IC50 of 0.2 nM. FS-694 inhibits the TNFα release in human whole blood with an IC50 of 35.0 nM[1].
CAS Number
[1417404-27-3]
UNSPSC
12352005
Target
P38 MAPK
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
FC(C=C1)=C(NC(C2=CC=CC=C2)=O)C=C1NC3=CC(CCC(C=CC(C(NCCN4CCOCC4)=O)=C5)=C5C6=O)=C6C=C3
Molecular Formula
C35H33FN4O4
Molecular Weight
592.66
References & Citations
[1]Walter NM, et al., Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine. J Med Chem. 2017 Oct 12;60 (19) :8027-8054.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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