EM12-SO2F

• Description :

  EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to investigate the CRBN. EM12-SO2F inhibits the degradation of IKZF1 by lenalidomide (HY-A0003) in MOLT4 cells[1][2]

• CAS Number :

  [2803819-61-4]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Fluorescent Dye

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/em12-so2f.html

• Purity :

  99.15

• Solubility :

  DMSO : 1 mg/mL (ultrasonic)

• Smiles :

  O=S(C1=CC2=C(CN(C(CC3)C(NC3=O)=O)C2=O)C=C1)(F)=O

• Molecular Formula :

  C13H11FN2O5S

• Molecular Weight :

  326.30

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Lang Zheng, et al. Development of covalent inhibitors: Principle, design, and application in cancer. Volume2, Issue 4.December 2023.|[2]Cruite JT, et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem Biol. 2022 Jul 8;3 (9) :1105-1110.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported