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EM12-SO2F

CAT: 0804-HY-W760183-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W760183-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to investigate the CRBN. EM12-SO2F inhibits the degradation of IKZF1 by lenalidomide in MOLT4 cells[1][2]
CAS Number
2803819-61-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fluorescent Dye
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/em12-so2f.html
Purity
99.15
Solubility
DMSO : 1 mg/mL (ultrasonic)
Smiles
O=S(C1=CC2=C(CN(C(CC3)C(NC3=O)=O)C2=O)C=C1)(F)=O
Molecular Formula
C13H11FN2O5S
Molecular Weight
326.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Lang Zheng, et al. Development of covalent inhibitors: Principle, design, and application in cancer. Volume2, Issue 4.December 2023.|[2]Cruite JT, et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem Biol. 2022 Jul 8;3 (9) :1105-1110.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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