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Capsaicin (Standard)

CAT: 0804-HY-10448R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10448R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Capsaicin (Standard) is the analytical standard of Capsaicin. This product is intended for research and analytical applications. Capsaicin ((E) -Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory and anti-cancer effects[1][2].
CAS Number
404-86-4
Product Name Alternative
(E) -Capsaicin (Standard)
UNSPSC
12352005
Hazard Statement
H300, H315, H317, H318, H334, H335
Target
Apoptosis; Autophagy; Endogenous Metabolite; Reference Standards; TRP Channel
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/capsaicin-standard.html
Purity
99.38
Smiles
CC(C)/C=C/CCCCC(NCC1=CC=C(O)C(OC)=C1)=O
Molecular Formula
C18H27NO3
Molecular Weight
305.41
Precautions
H300, H315, H317, H318, H334, H335
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched
Citation 01
Neurosci Bull. 2025 Oct 30.|ACS Omega. 2025 Aug 21;10 (34) :39192-39202.|Acta Pharmacol Sin. 2023 Apr;44 (4) :766-779.|Acta Pharmacol Sin. 2024 Jun;45 (6) :1160-1174.|Adv Mater. 2022 Mar;34 (11) :e2108435.|Adv Sci (Weinh) . 2025 Sep 15:e10102.|Am J Pathol. 2023 May;193 (5) :548-557.|Antioxidants (Basel) . 2022 May 20;11 (5) :1003.|bioRxiv. 2024 Jan 7.|BMC Med. 2024 Nov 4;22 (1) :504.|Brain Res Bull. 2024 Jun 1:211:110950.|Cancer Cell Int. 2024 Aug 28;24 (1) :300.|Cancer Cell Int. 2025 Oct 3;25 (1) :328.|Cell Biol Int. 2024 May 5.|Cell Discov. 2024 Nov 12;10 (1) :114.|Cell Metab. 2022 Dec 6;34 (12) :1999-2017.e10.|Cell Rep. 2023 Dec 2;42 (12) :113522.|Cell. 2024 Jun 6;187 (12) :2935-2951.e19.|Cell. 2025 Oct 24:S0092-8674 (25) 01129-8.|ChemMedChem. 2025 Jan 23:e202400913.|Cytotechnology. 2025 Aug;77 (4) :141.|EMBO J. 2025 Aug;44 (15) :4222-4251.|Eur J Pharmacol. 2024 Aug 16:176909.|Exp Cell Res. 2023 Dec 15;433 (2) :113856.|Exp Ther Med. 2023 May 15;26 (1) :318.|FASEB J. 2024 May 31;38 (10) :e23661.|FASEB J. 2025 Jul 15;39 (13) :e70778.|FASEB J. 2025 May 31;39 (10) :e70657.|Front Oncol. 2022 Mar 25;12:773654.|Front Pharmacol. 2025 Sep 29:16:1671461.|Inflammopharmacology. 2025 Jan;33 (1) :257-267.|Int Immunopharmacol. 2025 May 13:158:114807.|Int J Nanomedicine. 2024 Jan 3:19:73-90.|Invest Ophthalmol Vis Sci. 2025 Jun 2;66 (6) :28.|J Biol Chem. 2022 May;298 (5) :101847.|J Cardiovasc Pharmacol. 2022 Sep 1;80 (3) :430-441.|J Cardiovasc Transl Res. 2024 Dec;17 (6) :1415-1426.|J Funct Foods. 2023 Nov , 110, 105823.|J Inflamm Res. 2024 Apr 11:17:2245-2256.|J Inflamm Res. 2024 Jan 9:17:153-170.|J Inflamm Res. 2024 Jul 2:17:4257-4275.|J Med Chem. 2025 Nov 27;68 (22) :24011-24023.|J Mol Neurosci. 2024 Aug 20;74 (3) :79.|J Mol Neurosci. 2025 Oct 14;75 (4) :138.|J Neurochem. 2025 Jan;169 (1) :e16281.|J Neurosci. 2024 Jul 17:e0740242024.|J Periodontal Res. 2024 Aug;59 (4) :798-811.|J Vis Exp. 2025 Oct 3: (224) .|Microbiol Spectr. 2022 Dec 21;10 (6) :e0241022.|Mol Med Rep. 2024 Jul;30 (1) :110.|Mol Med Rep. 2025 Dec;32 (6) :322.|Mol Med. 2024 Sep 12;30 (1) :148.|Nat Commun. 2023 Apr 17;14 (1) :2182.|Neurotherapeutics.2024 May 21:e00377.|Ocul Surf. 2024 Oct:34:406-414.|Open Biol. 2025 Mar;15 (3) :240226.|Patent. US20250127769A1.|Pathol Res Pract. 2025 Sep:273:156143.|Pharmaceuticals (Basel) . 2024 Dec 15;17 (12) :1694.|Phytomedicine. 2022 Mar 21;100:154067.|Phytomedicine. 2025 Oct:146:157130.|Phytother Res. 2022 Feb;36 (2) :938-950.|Phytother Res. 2024 Sep;38 (9) :4386-4405.|Res Sq. 2024 Sep 22.|Res Sq. 2025 Oct 8.|Research Square Preprint. 2023 Oct 13.|Research Square Preprint. 2024 Sep 03.|Research Square Print. 2022 Jun.|SSRN. 2023 Sep 11.|Tissue Cell. 2025 Nov 21:99:103243.|Toxicol Appl Pharmacol. 2026 Jan:506:117655.

Chemical Information

Capsaicin

Capsaicin is a capsaicinoid. It has a role as a TRPV1 agonist, a non-narcotic analgesic and a voltage-gated sodium channel blocker.

CAS Number404-86-4
PubChem CID1548943
IUPAC Name(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
Molecular FormulaC18H27NO3
Molecular Weight305.4
XLogP3.6
Topological Polar Surface Area58.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count9
Heavy Atom Count22
Formal Charge0
Complexity341
SMILES
CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC
InChI
InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InChIKey
YKPUWZUDDOIDPM-SOFGYWHQSA-N
Chemical Structure
2D Structure
2D structure of Capsaicin
CAS: 404-86-4
CID: 1548943
Formula: C18H27NO3
MW: 305.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight305.4
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count9
Exact Mass305.19909372
Monoisotopic Mass305.19909372
Topological Polar Surface Area58.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity341
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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