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ML141

CAT: 0804-HY-12755-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12755-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7) . ML141 do not show cytotoxicity in multiple cell lines[1][2].
CAS Number
[71203-35-5]
Product Name Alternative
CID-2950007
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
Apoptosis; Ras
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ML141.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)C=C1)(N)=O
Molecular Formula
C22H21N3O3S
Molecular Weight
407.49
Precautions
H302, H315, H320, H335
References & Citations
[1]Hong L, et al. Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. J Biol Chem. 2013 Mar 22;288 (12) :8531-43.|[2]Surviladze Z, et al. A Potent and Selective Inhibitor of Cdc42 GTPase. Probe Reports from the NIH Molecular Libraries Program|[3]Hanin G, et al. Competing targets of microRNA-608 affect anxiety and hypertension. Hum Mol Genet. 2014 Sep 1;23 (17) :4569-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
456367-01ML141
SC6565-5mgML141 (Rho inhibitor)
MBS130831-01ML141(CID-2950007)
bs-60134C-01ML141 --- Cdc42 GTPase Inhibitor
217263Cdc42/Rac1 GTPase Inhibitor, ML141 (MLS00693334, CID2950007, (±) -4- (4,5-Dihydro-5- (4-methoxyphenyl) -3-phenyl-1H-pyrazol-1-yl) -benzenesulfonamide, (±) -4- (5- (4-Methoxyphenyl) -3-phenyl-4,5-dihydro-1H-pyrazol-1-yl) ) -benzenesulfonamide, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II)

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