SCD1 Recombinant Mouse Monoclonal Antibody [A9A11-R]

SCD1 Recombinant Mouse Monoclonal Antibody [A9A11-R]

• Description: Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA. Oleate and palmitoleate are major components of membrane phospholipids, cholesterol esters and alkyl-diacylglycerol. In humans, the enzyme is encoded by the SCD gene. Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism. It is responsible for forming a double bond in Stearoyl-CoA. This is how the monounsaturated fatty acid oleic acid is produced from the saturated fatty acid stearic-acid. A series of redox reactions, during which two electrons flow from NADH to flavoprotein cytochrome b5, then to the electron acceptor cytochrome b5 as well as molecular oxygen introduces a single double bond within a row of methylene fatty acyl-CoA substrates. The complexed enzyme adds a single double bond between the C9 and C10 of long-chain acyl-CoAs from de-novo synthesis. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with oxidation of a pair of donors resulting in the reduction of O to two molecules of water. The systematic name of this enzyme class is stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating). Other names in common use include Delta9-desaturase, acyl-CoA desaturase, fatty acid desaturase, and stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase. This enzyme participates in polyunsaturated fatty acid biosynthesis and ppar signaling pathway. It employs one cofactor, iron.
• Alternative Name: ACOD_HUMAN antibody Acyl-CoA desaturase antibody Delta (9)-desaturase antibody Delta-9 desaturase antibody Delta-9-Desaturase antibody FADS5 antibody Fatty acid desaturase antibody PRO0998 antibody SCD 1 antibody SCD antibody SCD1 antibody Stearoyl-CoA desaturase antibody
• Abbreviation: SCD, FADS5, SCD1, SCDOS
• Swiss Prot: O00767 Human, P13516 Mouse, P07308 Rat
• Cellular Locus: Endoplasmic reticulum membrane.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within human SCD1 aa 310-509 / 509.
• Isotype: IgG1
• Clone: A9A11-R
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB
• Positive Control: HepG2 cell lysate, HeLa cell lysate, HEK-293 cell lysate, SK-MEL-28 cell lysate, A375 cell lysate, A431 cell lysate, A549 cell lysate, mouse liver tissue lysate, rat liver tissue lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 42 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes