ROBO1 Recombinant Mouse Monoclonal Antibody [10E2-R]

ROBO1 Recombinant Mouse Monoclonal Antibody [10E2-R]

• Description: Specific cells in the midline separate the left and right halves of the central nervous system and play many roles in guiding the growth cone behavior. In vertebrate spinal cord, insect abdominal nerves and nematodes, midline cells produce induced cues, such as nectins and slits, respectively, as attractants and repellents. respectively. These cells can serve as gatekeepers to prevent axons from passing through the midline and to guide the growth cone in response to the switching of lead cues beyond the crossing. One such gatherer, Robo, is an axon guidance receptor that defines a new subfamily of proteins from fruit flies to mammalian conserved Ig superfamily proteins. Robo acts as a receptor for the repellent Slit and functions in a cell-autonomous manner Non-intersecting axons express high levels of Robo and cross axons to express low levels of Robo and then reach midline and high levels of crossover. Robo1 and Robo2 are two human homologs of Drosophila megalopolis. Robo1 is also homologous to the C. elegans gene sax3, while Robo2 is homologous to zebrafish genes.
• Product Name Alternative: Deleted in U twenty twenty antibody DUTT 1 antibody DUTT1 antibody FLJ21882 antibody H Robo 1 antibody H-Robo-1 antibody hRobo 1 antibody Robo 1 antibody Robo1 antibody ROBO1_HUMAN antibody Roundabout 1 antibody Roundabout axon guidance receptor homolog 1 antibody Roundabout homolog 1 antibody Roundabout homolog1 precurser antibody Roundabout1 antibody SAX 3 antibody SAX3 antibody
• Abbreviation: Deleted in U twenty twenty,H-Robo-1,Roundabout homolog 1,ROBO1
• CAS Number: 9000-83-3
• Swiss Prot: Q9Y6N7 Human, O89026 Mouse, O55005 Rat
• Cellular Locus: Cell membrane, Cell projection, axon, Endoplasmic reticulum-Golgi intermediate compartment membrane.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human ROBO1 aa 51-300 / 1,651.
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: MCF-7 cell lysate, NIH/3T3 cell lysate, rat brain tissue lysate, PC-12 cell lysate, RAW264.7 cell lysate, human breast tissue, human placenta tissue.
• Concentration: 2 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:200-1:600
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 181 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes