MCL-1/BCL-2-IN-1

MCL-1/BCL-2-IN-1

• CAS Number: 2493256-46-3
• UNSPSC Description: MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively[1].
• Target Antigen: Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mcl-1-bcl-2-in-1.html
• Purity: 99.86
• Solubility: DMSO : 10 mg/mL (ultrasonic)
• Smiles: O=C(N(CCNC(C1=CC=C(C(C)(C)C)C=C1)=O)C2=O)C3=CC=C(SC4=CC=C(Br)C=C4)C5=C3C2=CC=C5
• Molecular Weight: 587.53
• References & Citations: [1]Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported