MCL-1/BCL-2-IN-2

MCL-1/BCL-2-IN-2

• CAS Number: 2163793-44-8
• UNSPSC Description: MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor[1].
• Target Antigen: Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mcl-1-bcl-2-in-2.html
• Purity: 99.12
• Solubility: DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C1N(CCN)C(C2=CC=C(SC3=CC=C(Br)C=C3)C4=CC=CC1=C24)=O
• Molecular Weight: 427.31
• References & Citations: [1]Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported