OM99-2 (TFA)

• Description:

  OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 TFA is significantly advanced the development of BACE1 inhibitor[2]. OM99-2 has the potential for the research of the Alzheimer's disease[3].

• UNSPSC:

  12352209

• Target:

  Beta-secretase

• Type:

  Peptides

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/om99-2-tfa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC([C@H](CC1=CC=CC=C1)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](C)C[C@H](O)[C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@@H](N)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O

• Molecular Formula:

  C43H65F3N8O16

• Molecular Weight:

  1007.02

• References & Citations:

  [1]Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase) . J Am Chem Soc. 2000;122 (14) :3522-3523.|[2]Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4.|[3]Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38 (2) :89-119.|[4]Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125 (52) :16416-16422.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  BACE1

• CAS Number:

  [2504147-81-1]