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SQ 31844

CAT: 0804-HY-118185Size: 1 EachDry Ice: NoHazardous: No
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Description
SQ 31844 is a novel renin inhibitor belonging to the imidazolidinol class. This compound, which contains an imidazole ring in its active site binding group, has potent in vitro inhibition of primate renin, but not rat, pig, or dog renin. In conscious, sodium-deprived cynomolgus monkeys, both compounds produced dose-related inhibition of plasma renin activity (PRA) over a dose range of 0.001 to 1.0 μmol/kg, administered intravenously, with complete inhibition observed at the highest dose. However, a reduction in blood pressure was only observed when 10 μmol/kg was administered intravenously or by infusion. In sodium-replete monkeys, SQ 30774 inhibited the increase in arterial blood pressure and PRA following administration of exogenous monkey renin. When the compounds were administered orally at 50 μmol/kg, only SQ 31844 significantly inhibited PRA (80%) . In summary, the imidazolidinol renin inhibitors have potent inhibitory effects on renin in vitro and inhibit PRA and reduce arterial blood pressure in vivo.
CAS Number
115766-42-2
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sq-31844.html
Smiles
O=C([C@@H](N([C@H]([C@H](C1=NC=CN1)O)CC2CCCCC2)C([C@@H](NC(N3CCOCC3)=O)CC4=CC=CC=C4)=O)CC5=CNC=N5)N
Molecular Formula
C32H44N8O5
Molecular Weight
620.74
References & Citations
[1]Pharmacology of novel imidazole alcohol inhibitors of primate renin
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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