SQ-30741

• Description:

  SQ-30741 is a thromboxane A2 receptor antagonist. SQ-30741 reduces vasoconstriction in a feline pulmonary vascular bed model. SQ-30741 increases relaxation of aortic endothelium and vascular smooth muscle in adult rats in a spontaneously hypertensive rat model. SQ-30741 can be used in research on cardiovascular diseases such as hypertension[1][2].

• UNSPSC:

  12352005

• Target:

  Others

• Related Pathways:

  Others

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C(O)CCC/C=C\C[C@H]1[C@](O2)([H])CC[C@]2([H])[C@H]1CNC(CNC(CCCCCC)=O)=O

• Molecular Formula:

  C23H38N2O5

• Molecular Weight:

  422.56

• References & Citations:

  [1]McMahon TJ, et al. Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed. J Appl Physiol (1985) . 1991 Nov;71 (5) :2012-8.|[2]Küng CF, et al. Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Hypertension. 1995 Feb;25 (2) :194-200.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [107332-47-8]