SQ-33600

CAT: 0804-HY-19107Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19107Size:1 Each
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Description
SQ-33600 is an HMG-CoA reductase inhibitor. SQ-33600 has cholesterol-lowering activity. SQ-33600 possesses cell-type selectivity, with much higher inhibitory activity on rat hepatocytes (IC50: 93 nM) than on human skin fibroblasts (IC50: 14200 nM) . SQ-33600 can be used in the research of diseases such as hypercholesterolemia[1][2].
CAS Number
[133983-25-2]
UNSPSC
12352005
Target
HMG-CoA Reductase (HMGCR)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Endocrinology; Metabolic Disease
Smiles
O=C(C[C@@H](CP(C#CC(N1C2=CC=C(C=C2)F)=C(C3=C1C=CC=C3)C(C)C)(O[Na])=O)O)O[Na]
Molecular Formula
C23H21FNNa2O5P
Molecular Weight
487.37
References & Citations
[1]Wang-Iverson D, et al. Determination of SQ 33,600, a phosphinic acid containing HMG CoA reductase inhibitor, in human serum by high-performance liquid chromatography combined with ionspray mass spectrometry. Biol Mass Spectrom. 1992 Apr;21 (4) :189-94.|[2]Jagoda E, et al. Radioimmunoassay for hydroxyphosphinyl-3-hydroxybutanoic acid (SQ 33,600), a hypocholesterolemia agent. Ther Drug Monit. 1993 Jun;15 (3) :213-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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