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(+) -Kavain (Standard)

CAT: 0804-HY-B1671RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1671RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(+) -Kavain (Standard) is the analytical standard of (+) -Kavain. This product is intended for research and analytical applications. (+) -Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels[1]. (+) -Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy[2]. (+) -Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied[4].
CAS Number
500-64-1
UNSPSC
12352005
Target
Calcium Channel; GABA Receptor; Reference Standards; Sodium Channel
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/plus-kavain-standard.html
Smiles
O=C1C=C(OC)C[C@H](/C=C/C2=CC=CC=C2)O1
Molecular Formula
C14H14O3
Molecular Weight
230.26
References & Citations
[1]Bradić I, et al. [Hirschsprung's disease -- therapy and results]. Acta Chir Iugosl. 1975;22 (2) :183-95.|[2]Chua HC, et al. Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism. PLoS One. 2016 Jun 22;11 (6) :e0157700.|[3]G. Boonen, et al. In vivo Effects of the Kavapyrones (+) -Dihydromethysticin and (±) -Kavain on Dopamine, 3,4-Dihydroxyphenylacetic Acid, Serotonin and 5-Hydroxyindoleacetic Acid Levels in Striatal and Cortical Brain Regions. Planta Medica 64 (1998) 507-510.|[4]Tang X, et al. Kavain Inhibition of LPS-Induced TNF-α via ERK/LITAF. Toxicol Res (Camb) . 2016 Jan 1;5 (1) :188-196.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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