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Falnidamol

CAT: 0804-HY-10322-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10322-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM) . Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity[1][2].
CAS Number
196612-93-8
Product Name Alternative
BIBX 1382
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BIBX-1382.html
Purity
99.41
Solubility
DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=CC(NC2=NC=NC3=CN=C(NC(CC4)CCN4C)N=C23)=CC=C1F
Molecular Formula
C18H19ClFN7
Molecular Weight
387.84
Precautions
H302, H315, H319, H335
References & Citations
[1]Solca FF, et al. Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J Pharmacol Exp Ther. 2004 Nov;311 (2) :502-9.|[2]Dittrich Ch, et al. Phase I and pharmacokinetic study of BIBX 1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration. Eur J Cancer. 2002 May;38 (8) :1072-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2

Alternative Products

CatalogName
GTR19178867-01Falnidamol
A11334-100Falnidamol (BIBX 1382) 100mg
A11334-25Falnidamol (BIBX 1382) 25mg
A11334-10Falnidamol (BIBX 1382) 10mg
A11334-5Falnidamol (BIBX 1382) 5mg
A11334-200Falnidamol (BIBX 1382) 200mg
A11334-50Falnidamol (BIBX 1382) 50mg
A11334-2Falnidamol (BIBX 1382) 2mg
A11334-10mM-DFalnidamol (BIBX 1382) 10mM * 1mL in DMSO

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