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LTA4H-IN-5

CAT: 0804-HY-162710Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162710Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LTA4H-IN-5 (Compound H122) is an orally active inhibitor for leukotriene A4 hydrolase (LTA4H), that inhibits the LTA4H aminopeptidase and LTA4H hydrolase with IC50 of 0.38 nM and 16.93 nM. LTA4H-IN-5 exhibits good pharmacokinetic characteristics in C57 mice and ameliorates the DNBS-induced ulcerative enteritis in rat models[1].
UNSPSC
12352211
Target
Aminopeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lta4h-in-5.html
Smiles
ClC1=CN=C(OC2=CC(C)=C(C3=NOC(C[C@H](CC(O)=O)N)=N3)C=C2)C(F)=C1.[H]Cl
Molecular Formula
C18H17Cl2FN4O4
Molecular Weight
443.26
References & Citations
[1]Li Xin, et al., LTA4H inhibitors and uses thereof. CN118307534A.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LTA4H

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