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Bendamustine (hydrochloride) (Standard)

CAT: 0804-HY-B0077R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0077R-01Size:5 mg
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Description
Bendamustine (hydrochloride) (Standard) is the analytical standard of Bendamustine (hydrochloride) . This product is intended for research and analytical applications. Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].
CAS Number
3543-75-7
Product Name Alternative
SDX-105 (Standard)
UNSPSC
12352005
Target
Apoptosis; DNA Alkylator/Crosslinker; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bendamustine-hydrochloride-standard.html
Smiles
CN1C(C=CC(N(CCCl)CCCl)=C2)=C2N=C1CCCC(O)=O.Cl
Molecular Formula
C16H22Cl3N3O2
Molecular Weight
394.72
References & Citations
[1]Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14 (1) :309-17.|[2]Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25 (5) :1108-17.|[3]Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167 (4) :881-91.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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