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Bendamustine-d8 (hydrochloride)

CAT: 0804-HY-B0077S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0077S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bendamustine-d8 (hydrochloride) is deuterium labeled Bendamustine (hydrochloride) . Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].
CAS Number
1185068-23-8
Product Name Alternative
SDX-105-d8
UNSPSC
12352005
Target
Apoptosis; DNA Alkylator/Crosslinker; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(O)CCCC1=NC2=CC(N(C([2H])([2H])C([2H])(Cl)[2H])C([2H])([2H])C([2H])(Cl)[2H])=CC=C2N1C.Cl
Molecular Formula
C16H14D8Cl3N3O2
Molecular Weight
402.77
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167 (4) :881-91.|[3]Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25 (5) :1108-17.|[4]Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14 (1) :309-17.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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