Bendamustine (hydrochloride hydrate)

CAT: 0804-HY-13567ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-13567ASize:1 Each
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Description
Bendamustine hydrochloride hydrate (SDX-105 hydrate), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride hydrate activates DNA-damage stress response and apoptosis. Bendamustine hydrochloride hydrate has potent alkylating, anticancer and antimetabolite properties[1].
CAS Number
[1374784-02-7]
Product Name Alternative
SDX-105 (hydrate)
UNSPSC
12352005
Target
Apoptosis; DNA Alkylator/Crosslinker
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C(CCCC1=NC2=C(N1C)C=CC(N(CCCl)CCCl)=C2)O.Cl.O
Molecular Formula
C16H24Cl3N3O3
Molecular Weight
412.74
References & Citations
[1]Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14 (1) :309-17.|[2]Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25 (5) :1108-17. |[3]Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167 (4) :881-91.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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