Bendamustine (Standard)

• Description :

  Bendamustine (Standard) is the analytical standard of Bendamustine. This product is intended for research and analytical applications. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[1].

• UNSPSC :

  12352100

• Target :

  Apoptosis; DNA Alkylator/Crosslinker; Reference Standards

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Others

• Field of Research :

  Cancer

• Smiles :

  O=C(O)CCCC1=NC2=CC(N(CCCl)CCCl)=CC=C2N1C

• Molecular Formula :

  C16H21Cl2N3O2

• Molecular Weight :

  358.26

• References & Citations :

  [1]Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14 (1) :309-17.|[2]Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25 (5) :1108-17.|[3]Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167 (4) :881-91.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [16506-27-7]