RS-56812

• Description:

  RS-56812 is a partial agonist of the 5-HT3 receptor. RS-56812 significantly enhances the propulsive peristalsis of the colon. RS-56812 indirectly enhances cholinergic neurotransmission and improves the working memory performance of non-human primates. RS-56812 is used in research on diarrhea/colon peristalsis and cognitive disorders (such as Alzheimer's disease) [1][2].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(NC1CN2CCC1CC2)C(C3=CN(C)C4=C3C=CC=C4)=O

• Molecular Formula:

  C18H21N3O2

• Molecular Weight:

  311.38

• References & Citations:

  [1]Terry AV Jr, et al. The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys. Neuroreport. 1996 Dec 20;8 (1) :49-54. |[2]Boakye PA, et al. 5-HT (3) and 5-HT (4) receptors contribute to the anti-motility effects of Garcinia buchananii bark extract in the guinea-pig distal colon. Neurogastroenterol Motil. 2012 Jan;24 (1) :e27-40.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT3 Receptor

• CAS Number:

  [143137-35-3]