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(-) -JM-1232

CAT: 0804-HY-108035Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-108035Size:1 Each
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Description
(-) -JM-1232 (MR04A3) targets GABA A receptors and exerts its analgesic effects by binding to the benzodiazepine binding site of GABA A receptors. (-) -JM-1232 demonstrates potent analgesic effects in mice against acute thermal stimuli, mechanically induced pain, and visceral pain, with CI50 values of 2.96, 3.06, and 2.27 mg/kg, respectively. (-) -JM-1232 can be used in research related to pain and analgesia[1][2].
CAS Number
1013427-48-9
Product Name Alternative
MR04A3
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/minus-jm-1232.html
Smiles
O=C(N1CCN(CC1)C)C[C@@H]2C3=C(C=C4C(CCC4)=C3)C(N2C5=CC=CC=C5)=O
Molecular Formula
C24H27N3O2
Molecular Weight
389.49
References & Citations
[1]Nishiyama T, et al. Antinociceptive property of intrathecal and intraperitoneal administration of a novel water-soluble isoindolin-1-one derivative, JM 1232 (-) in rats. Eur J Pharmacol. 2008 Oct 31;596 (1-3) :56-61. |[2]Chiba S, et al. The antinociceptive effects and pharmacological properties of JM-1232 (-) : a novel isoindoline derivative. Anesth Analg. 2009 Mar;108 (3) :1008-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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