JM-9

• Description:

  JM-9 is a inhibitor of MD2. JM-9 suppresses high glucose and palmitic acid -induced inflammation in MPMs. JM-9 improves diabetic kidney disease by inhibiting MD2-mediated inflammation[1].

• UNSPSC:

  12352005

• Target:

  Toll-like Receptor (TLR)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/jm-9.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC(F)(F)C1=C(/C=C2CCCC(/C\2=N\O)=C\C3=CC=CC=C3C(F)(F)F)C=CC=C1

• Molecular Formula:

  C22H17F6NO

• Molecular Weight:

  425.37

• References & Citations:

  [1]Wang M, et al. Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice. Biomed Pharmacother. 2023 Dec;168:115660.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported