ERD-1233

• UNSPSC Description:

  ERD-1233 is a potent and orally active estrogen receptor PROTAC degrader, with the DC50 of 0.9 nM. ERD-1233 plays an important role in ER+ breast cancer research (Pink: ligand for target protein (HY-201580); Black: linker (HY-W889109); Blue: E3 ligase ligand (HY-W1009348))[1].

• Target Antigen:

  Estrogen Receptor/ERR; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/erd-1233.html

• Smiles:

  OC1=CC=C2[C@@H](C3=CC=C(N4CCC5(CC4)CC(CN6C[C@H]7N(CC6)C(C(OC7)=C8CN9[C@@H]%10C(NC(CC%10)=O)=O)=CC=C8C9=O)CO5)C=C3)[C@@H](C%11=CC=CC=C%11)CCC2=C1

• Molecular Weight:

  807.98

• References & Citations:

  [1]Ranjan Kumar Acharyya, et al. Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer. J Med Chem. 2024 Nov 14;67(21):19010-19037.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported