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Forigerimod (TFA)

CAT: 0804-HY-105037A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105037A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Forigerimod TFA (IPP-201101 TFA) is a CD4 T-cell modulator. Forigerimod TFA is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod TFA can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) [1][2][3][4].
Product Name Alternative
IPP-201101 (TFA)
UNSPSC
12352209
Target
Autophagy
Type
Peptides
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/forigerimod-tfa.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(C(F)(F)F)O.OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCSC)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@@H](N)CCCNC(N)=N)=O)=O)CC2=CN=CN2)=O)=O)=O)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](COP(O)(O)=O)C(NCC(N[C@@H](CCCCN)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)CC6=CC=C(C=C6)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C117H181N34O32PS.xC2HF3O2
References & Citations
[1]Aikaterini Thanou, et al. Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys. |[2]Sean Robinson, et al. Potential for Antigen-Specific Tolerizing Immunotherapy in Systematic Lupus Erythematosus. Front Immunol. 2021 Jul 16;12:654701.|[3]Robert Zimmer, et al. Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial. Ann Rheum Dis. 2013 Nov;72 (11) :1830-5.|[4]Baihui Li, et al. Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide. J Autoimmun. 2018 Jun;90:132-145.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
Phase 3

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