NH2-methylpropanamide-Exatecan (TFA)

CAT:

804-HY-156686-02

Size:

5 mg

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CAS Number: 1817857-35-4
UNSPSC Description: NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan (HY-13631), which is the common ADC Cytotoxin used in the synthesis of ADC. Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].
Target Antigen: ADC Cytotoxin; Topoisomerase
Type: ADC Related
Related Pathways: Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Applications: Cancer-programmed cell death
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/nh2-methylpropanamide-exatecan-tfa.html
Solubility: 10 mM in DMSO
Smiles: OC(C(F)(F)F)=O.NC[C@H](C)C(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O
Molecular Weight: 634.58
References & Citations: [1]Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.
Shipping Conditions: Blue Ice
Clinical Information: No Development Reported

Cat	Name
HY-156686-02	NH2-methylpropanamide-Exatecan (TFA)
HY-156686-01	NH2-methylpropanamide-Exatecan (TFA)
HY-145397-06	(4-NH2)-Exatecan
HY-145397-01	(4-NH2)-Exatecan
HY-145397-05	(4-NH2)-Exatecan
HY-145397-04	(4-NH2)-Exatecan
HY-145397-03	(4-NH2)-Exatecan
HY-145397-02	(4-NH2)-Exatecan
HY-145397S-03	(4-NH2)-Exatecan-d5
HY-145397S-02	(4-NH2)-Exatecan-d5

Cat	Name
MBS5819560	NH2-methylpropanamide-Exatecan TFA
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T40159-5mg	(4-NH2)-Exatecan
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