Products for Research Use Only

BAN ORL 24

CAT: 0804-HY-13222-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13222-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic[1].
CAS Number
1401463-54-4
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BAN-ORL-24.html
Purity
99.68
Solubility
DMSO : ≥ 150 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1N(CC2=CC=CC=C2)CCC1)NCCCN3CCC4(CC3)OCC5=C4C=CC=C5.[H]Cl.[H]Cl
Molecular Formula
C27H37Cl2N3O2
Molecular Weight
506.51
References & Citations
[1]Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50.|[2]Tao Hou, et al. Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. J Ethnopharmacol|[3]Chao, et al. BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine. Neuropharmacology 166, 107678 (2020) .
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
NOP Receptor/ORL1