4-Hydroxycoumarin (Standard)

• Description :

  4-Hydroxycoumarin (Standard) is the analytical standard of 4-Hydroxycoumarin. This product is intended for research and analytical applications. 4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects[1][2][3][4].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Bacterial; Endogenous Metabolite; Reference Standards

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease; Others

• Field of Research :

  Infection; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/4-hydroxycoumarin-standard.html

• Purity :

  99.26

• Smiles :

  O=C1C=C(O)C2=CC=CC=C2O1

• Molecular Formula :

  C9H6O3

• Molecular Weight :

  162.14

• Precautions :

  H302

• References & Citations :

  [1]Mohammadi Ziarani G, et al. The molecular diversity scope of 4-hydroxycoumarin in the synthesis of heterocyclic compounds via multicomponent reactions. Mol Divers. 2019 Jan 29. doi: 10.1007/s11030-019-09918-7.|[2]Velasco-Velázquez MA, et al. 4-Hydroxycoumarin disorganizes the actin cytoskeleton in B16-F10 melanoma cells but not in B82 fibroblasts, decreasing their adhesion to extracellular matrix proteins and motility. Cancer Lett. 2003 Aug 20;198 (2) :179-86.|[3]Salinas-Jazmín N, et al. Antimetastatic, antineoplastic, and toxic effects of 4-hydroxycoumarin in a preclinical mouse melanoma model. Cancer Chemother Pharmacol. 2010 Apr;65 (5) :931-40.|[4]Luchini AC, et al. Intestinal anti-inflammatory activity of coumarin and 4-hydroxycoumarin in the trinitrobenzenesulphonic acid model of rat colitis. Biol Pharm Bull. 2008 Jul;31 (7) :1343-50.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C, sealed storage, away from light and moisture

• Scientific Category :

  Reference Standards

• CAS Number :

  [1076-38-6]