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3-Acetyl-7-Hydroxycoumarin

CAT: 0804-HY-W267205-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W267205-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
3-Acetyl-7-Hydroxycoumarin (Compound 2) is a high selective 17-beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor. 3-Acetyl-7-Hydroxycoumarin shows a significant improvement of the inhibitory potency, with 57% inhibition of 17β-HSD1 at 6 μM. 3-Acetyl-7-Hydroxycoumarin is promising for research of hormone-dependent diseases, such as breast cancer and endometriosis[1].
CAS Number
10441-27-7
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
17β-HSD
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Endocrinology
Smiles
CC(=O)C1=CC2=C(C=C(C=C2)O)OC1=O
Molecular Formula
C11H8O4
Molecular Weight
204.18
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Starcević S, et al. Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1. J Med Chem. 2011 Jan 13;54 (1) :248-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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