3-Hydroxycoumarin

• Description:

  3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Lipoxygenase

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/3-hydroxycoumarin.html

• Purity:

  99.30

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1C (O) =CC2=CC=CC=C2O1

• Molecular Formula:

  C9H6O3

• Molecular Weight:

  162.14

• Precautions:

  H302

• References & Citations:

  [1]Born SL, et al. Synthesis and reactivity of coumarin 3,4-epoxide. Drug Metab Dispos. 1997;25 (11) :1318‐1324.|[2]Alavi SJ, Sadeghian H, Seyedi SM, Salimi A, Eshghi H. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem Biol Drug Des. 2018;91 (6) :1125‐1132.|[3]Asthana S, et al. Structure-Activity Relationship Study of Hydroxycoumarins and Mushroom Tyrosinase. J Agric Food Chem. 2015;63 (32) :7236‐7244.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  939-19-5