Ganoderic acid SZ

• Description :

  Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity. Ganoderic acid SZ shows stronger activity than the positive control atorvastatin in inhibiting HMG-CoA reductase. Ganoderic acid SZ exhibits significant inhibition of yeast-derived α-glucosidase with IC50 values achieved at very low concentrations. Ganoderic acid SZ also exhibits cytotoxicity against K562 cells with IC values in the range of 10-20 μM[1].

• UNSPSC :

  12352211

• Target :

  HMG-CoA Reductase (HMGCR)

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/ganoderic-acid-sz.html

• Smiles :

  C[C@]12C3=CC[C@](C(C)(C(CC4)=O)C)([H])[C@@]4(C)C3=CC[C@@]1([C@@](CC2)([H])[C@H](C)CC/C=C(C)\C(O)=O)C

• Molecular Formula :

  C30H44O3

• Molecular Weight :

  452.67

• References & Citations :

  [1]Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [865543-37-9]