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SB 258719

CAT: 0804-HY-U00443-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-U00443-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB 258719 is a selective 5-HT7 receptor antagonist with high affinity (pKi=7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease[1][2][3].
CAS Number
195199-95-2
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SB_258719.html
Purity
99.0
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=CC(C)=C1)(N(C)[C@H](C)CCN2CCC(C)CC2)=O
Molecular Formula
C18H30N2O2S
Molecular Weight
338.51
Precautions
H315, H319, H335
References & Citations
[1]Thomas DR, et al. Functional characterisation of the human cloned 5-HT7 receptor (long form) ; antagonist profile of SB-258719. Br J Pharmacol. 1998;124 (6) :1300-1306.|[2]Guscott MR, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003;44 (8) :1031-1037.|[3]Fatima S, et al. 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. Mol Oncol. 2016;10 (2) :195-212.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT7 Receptor; MUC3

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