SGLT2-IN-1

• Description:

  SGLT2-IN-1 (Compound 5) is an inhibitor for sodium-dependent glucose cotransporter (SGLT2), with IC50 of 33 nM in CHO cells transfected with human SGLT2. SGLT2-IN-1 is selective for SGLT2 over SGLT1. SGLT2-IN-1 is an active metabolite of dapagliflozinactive metabolite of dapagliflozin[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H319, H372, H411

• Target:

  SGLT

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/sglt2-in-1.html

• Purity:

  99.82

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1[C@H](C2=CC(CC3=CC=C(C=C3)O)=C(C=C2)Cl)O[C@@H]([C@H]([C@@H]1O)O)CO

• Molecular Formula:

  C19H21ClO6

• Molecular Weight:

  380.82

• Precautions:

  H302, H319, H372, H411

• References & Citations:

  [1]Lansdell MI, et al., Design and synthesis of fluorescent SGLT2 inhibitors. Bioorg Med Chem Lett. 2008 Sep 15;18 (18) :4944-7. |[2]Xu B, Feng Y, et al. C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2011 Aug 1;21 (15) :4465-70.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  SGLT2

• CAS Number:

  [864070-37-1]