SGLT2-IN-2

CAT: 0804-HY-174400-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-174400-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SGLT2-IN-2 (Compound E9) is an inhibitor of SGLT2. SGLT2-IN-2 significantly enhances the inhibition of SGLT2, NHE1, and SOD enzyme activity. SGLT2-IN-2 has protective effect on the glucose-free DMEM-induced injured cardiomyocytes. SGLT2-IN-2 significantly improves cardiac function in TAC-induced HF mice and inhibits cardiomyocyte hypertrophy as well as collagen deposition. SGLT2-IN-2 can ameliorate myocardial tissue damage and enhance mitochondrial autophagy in injured cardiomyocytes, thereby increasing survival rates in HF mice[1].
UNSPSC
12352005
Target
Autophagy; Na+/H+ Exchanger (NHE) ; SGLT; SOD
Related Pathways
Autophagy; Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@@H](CO)O[C@@H](OC2=CC=C(C3=CN(CC4=CC=CN=C4)N=C3C)C=C2)[C@H](O)[C@H]1O
Molecular Formula
C22H25N3O6
Molecular Weight
427.45
References & Citations
[1]Liu, Y., et al., (2025) . Design, synthesis and evaluation of anti-heart failure activity of O-glucoside derivatives. European journal of medicinal chemistry, 296, 117802.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-I1120-01SGLT2-IN-1
HY-180201SGLT2-IN-4
HY-178167SGLT2-IN-3
HY-I1120RSGLT2-IN-1 (Standard)
HY-145357SGLT1/2-IN-2
HY-169821SGLT1/2-IN-8
HY-138944SGLT1/2-IN-1
HY-W011060-01Cryptand 2.2.2
HY-B1500-012,2,2-Trichloroethanol
HY-N2048-012,2':5',2''-Terthiophene

Alternative Products

CatalogName
T210997-01SGLT2-IN-2
MBS9233092-01SGLT2 Antibody
MBS544463-01SGLT2 Peptide
BA6945-5SGLT2-IN-1
514150SGLT2 discontinued
PVT7137SGLT2 Plasmid
FY-AB45405-01Anti-Sodium/Glucose Cotransporter 2 (SGLT2)
abx178413-01Sodium/Glucose Cotransporter 2 (SGLT2) Antibody
TRV-0013076-01Recombinant Sodium/Glucose Cotransporter 2 (SGLT2)
MBS7609761-01Recombinant Human SGLT2

Popular Products