CFM-5

• Description :

  CFM-5 inhibits CARP-1/CCAR1-APC-2 interaction with an IC50 value of 0.75 μM. CFM-5 inhibits medulloblastoma (MB) cell proliferation and induces apoptosis[1][2].

• UNSPSC :

  12352005

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cfm-5.html

• Concentration :

  10mM

• Purity :

  99.48

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1N(C2=C(C13SC(C4=CC=CC=C4)=NN3)C=C(C=C2)Br)CCC5=CC=CC=C5

• Molecular Formula :

  C23H18BrN3OS

• Molecular Weight :

  464.38

• References & Citations :

  [1]Abdelkader E Ashour, et al. CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS One. 2013 Jun 24;8 (6) :e66733.|[2]Magesh Muthu, et al. CARP-1/CCAR1: a biphasic regulator of cancer cell growth and apoptosis. Oncotarget. 2015 Mar 30;6 (9) :6499-510.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [639507-03-2]