CFM-1

• Description :

  CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC50 value of 4.1 μM. CFM-1 induces G2M cell cycle arrest and suppresses viabilities of human breast cancer cells[1].

• UNSPSC :

  12352005

• Target :

  APC

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cfm-1.html

• Smiles :

  O=C1NC2=C(C=C(Br)C=C2C)/C1=C(SC(N3)=S)\C3=O

• Molecular Formula :

  C12H7BrN2O2S2

• Molecular Weight :

  355.23

• References & Citations :

  [1]Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC) -2-cell cycle and apoptosis regulatory protein (CARP) -1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286 (44) :38000-38017.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1380448-60-1]