CFM-4

• Description :

  CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cfm-4.html

• Purity :

  98.85

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C1N(CC2=CC=CC=C2Cl)C3=C(C=CC=C3)C14SC(C5=CC=CC=C5)=NN4

• Molecular Formula :

  C22H16ClN3OS

• Molecular Weight :

  405.90

• References & Citations :

  [1]Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC) -2-cell cycle and apoptosis regulatory protein (CARP) -1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286 (44) :38000-38017.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [331458-02-7]