CFM-4

CAT: 0804-HY-103255-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103255-01Size:5 mg
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Description
CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells[1].
CAS Number
[331458-02-7]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cfm-4.html
Purity
98.85
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(CC2=CC=CC=C2Cl)C3=C(C=CC=C3)C14SC(C5=CC=CC=C5)=NN4
Molecular Formula
C22H16ClN3OS
Molecular Weight
405.90
References & Citations
[1]Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC) -2-cell cycle and apoptosis regulatory protein (CARP) -1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286 (44) :38000-38017.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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