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Fluticasone (propionate)

CAT: 0804-HY-B0154-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0154-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].
CAS Number
80474-14-2
UNSPSC
12352100
Hazard Statement
H315, H319, H320
Target
ADC Payload; Endogenous Metabolite; Enterovirus; Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Infection; Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Fluticasone-propionate.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C(CC)O[C@@]([C@]([C@@]1([H])C2)(C[C@H](O)[C@](F)([C@]3(C=C4)C)[C@@]1([H])C[C@H](F)C3=CC4=O)C)([C@@H]2C)C(SCF)=O
Molecular Formula
C25H31F3O5S
Molecular Weight
500.57
Precautions
H315, H319, H320
References & Citations
[1]Singanayagam A, et al. Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. Lancet. 2015 Feb 26;385 Suppl 1:S88.|[2]Bryson HM, et al. Intranasal fluticasone propionate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in allergic rhinitis. Drugs. 1992;43 (5) :760-775.|[3]Johnson M. The anti-inflammatory profile of fluticasone propionate. Allergy. 1995;50 (23 Suppl) :11-14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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