Fluticasone

• UNSPSC Description:

  Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells[1][2].

• Target Antigen:

  Glucocorticoid Receptor; Smo

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Stem Cell/Wnt;Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Infection; Endocrinology; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/fluticasone.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@]([C@](O)1C(SCF)=O)(C[C@@H]2O)[C@](C[C@H]1C)([H])[C@@](C[C@@H]3F)([H])[C@]2([C@](C3=CC4=O)(C=C4)C)F

• Molecular Weight:

  444.51

• References & Citations:

  [1]Seidel P, et al. Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies. Respir Res. 2012 Oct 4. 13(1):90.|[2]Wang J, et al. Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A. 2010 May 18. 107(20):9323-8. |[3]Ying Wang, et al. Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells. Front. Cell. Infect. Microbiol., 2020 Jun. |[4]Singanayagam A, et al. Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. Lancet. 2015 Feb 26. 385(Suppl 1):S88.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  90566-53-3