Fluticasone

CAT: 0804-HY-B0603-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0603-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells[1][2].
CAS Number
[90566-53-3]
UNSPSC
12352100
Hazard Statement
H315, H319, H320
Target
Glucocorticoid Receptor; Smo
Type
Reference compound
Related Pathways
Immunology/Inflammation; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fluticasone.html
Concentration
10mM
Purity
98.70
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@]([C@](O)1C(SCF)=O)(C[C@@H]2O)[C@](C[C@H]1C)([H])[C@@](C[C@@H]3F)([H])[C@]2([C@](C3=CC4=O)(C=C4)C)F
Molecular Formula
C22H27F3O4S
Molecular Weight
444.51
Precautions
H315, H319, H320
References & Citations
[1]Seidel P, et al. Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies. Respir Res. 2012 Oct 4. 13 (1) :90.|[2]Wang J, et al. Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A. 2010 May 18. 107 (20) :9323-8. |[3]Ying Wang, et al. Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells. Front. Cell. Infect. Microbiol., 2020 Jun. |[4]Singanayagam A, et al. Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. Lancet. 2015 Feb 26. 385 (Suppl 1) :S88.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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