Fluticasone furoate

• UNSPSC Description:

  Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment[1][2].

• Target Antigen:

  Glucocorticoid Receptor

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/fluticasone-furoate.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C[C@@]12[C@](C(SCF)=O)(OC(C3=CC=CO3)=O)[C@H](C)C[C@@]1([H])[C@]4([H])C[C@H](F)C5=CC(C=C[C@]5(C)[C@@]4(F)[C@@H](O)C2)=O

• Molecular Weight:

  538.58

• References & Citations:

  [1]Giavina-Bianchi P, et al. Fluticasone furoate nasal spray in the treatment of allergic rhinitis. Ther Clin Risk Manag. 2008 Apr;4(2):465-72.|[2]Alizadeh Z, et al. Asthma phenotypes and T-bet protein expression in cells treated with Fluticasone Furoate/Vilanterol. Pulm Pharmacol Ther. 2020 Feb;60:101886.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  397864-44-7