Products for Research Use Only

Eicosapentaenoic Acid (Standard)

CAT: 0804-HY-B0660R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0660R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eicosapentaenoic Acid (Standard) is the analytical standard of Eicosapentaenoic Acid. This product is intended for research and analytical applications. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA) . Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ) . Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].
CAS Number
10417-94-4
Product Name Alternative
EPA (Standard) ; Timnodonic acid (Standard)
UNSPSC
12352211
Target
Endogenous Metabolite; Histone Demethylase; Reference Standards
Type
Reference Standards
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/eicosapentaenoic-acid-standard.html
Purity
99.86
Smiles
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
Molecular Formula
C20H30O2
Molecular Weight
302.45
References & Citations
[1]Martins, J.G., EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr, 2009. 28 (5) : p. 525-42.|[2]Shun-he Wang, et al. Endogenous omega-3 long-chain fatty acid biosynthesis from alpha-linolenic acid is affected by substrate levels, gene expression, and product inhibition. RSC Adv., 2017, 7, 40946-40951.|[3]Miaozhen Pan, et al. Dietary ω-3 polyunsaturated fatty acids are protective for myopia. Proc Natl Acad Sci U S A. 2021 Oct 26;118 (43) :e2104689118.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards