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Eicosapentaenoic Acid

CAT: 0804-HY-B0660-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0660-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA) . Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ) . Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].
CAS Number
10417-94-4
Product Name Alternative
EPA; Timnodonic acid
UNSPSC
12352211
Hazard Statement
H227, H314, H318
Target
Endogenous Metabolite; Histone Demethylase
Type
Natural Products
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Eicosapentaenoic-Acid.html
Purity
99.86
Solubility
DMSO : ≥ 30 mg/mL
Smiles
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
Molecular Formula
C20H30O2
Molecular Weight
302.45
Precautions
H227, H314, H318
References & Citations
[1]Martins, J.G., EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr, 2009. 28 (5) : p. 525-42.|[2]Shun-he Wang, et al. Endogenous omega-3 long-chain fatty acid biosynthesis from alpha-linolenic acid is affected by substrate levels, gene expression, and product inhibition. RSC Adv., 2017, 7, 40946-40951.|[3]Miaozhen Pan, et al. Dietary ω-3 polyunsaturated fatty acids are protective for myopia. Proc Natl Acad Sci U S A. 2021 Oct 26;118 (43) :e2104689118.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite

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