HSD17B13-IN-86

• Description :

  HSD17B13-IN-86 (Compound 188) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-86 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].

• UNSPSC :

  12352005

• Target :

  17β-HSD

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/hsd17b13-in-86.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=C(Cl)C=C(C(NC2=C(C(NCC3=NN(C)C4=C3C=CC=C4)=O)N=CS2)=O)C=C1Cl

• Molecular Formula :

  C20H15Cl2N5O3S

• Molecular Weight :

  476.34

• References & Citations :

  [1]Anandan S K, et al. Dichlorophenol HSD17B13 inhibitors and uses thereof. U.S., WO2022103960. 2023-11-28.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2770247-78-2]