Tregitope 289

• Description:

  Tregitope 289 is a peptide derived from the Fc region of immunoglobulin G (IgG) and is a highly conserved T cell epitope that stimulates the expansion of natural regulatory T cells. Co-delivery of Tregitope 289 with type 1 diabetes (T1D) antigens delays the development of hyperglycemia and reduces the incidence of diabetes in the NOD mouse model. Tregitope 289 can be used to study T1D and other autoimmune diseases[1].

• UNSPSC:

  12352209

• Target:

  Others

• Type:

  Peptides

• Related Pathways:

  Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Others

• Assay Protocol:

  https://www.medchemexpress.com/tregitope-289.html

• Smiles:

  O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N

• Molecular Formula:

  C115H173N31O36

• Molecular Weight:

  2565.79

• References & Citations:

  [1]Cousens L P, et al. Application of IgG‐derived natural Treg epitopes (IgG Tregitopes) to antigen‐specific tolerance induction in a murine model of type 1 diabetes[J]. Journal of diabetes research, 2013, 2013 (1) : 621693.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported