AN-2898

• Description :

  AN-2898 is a selective PDE4 inhibitor with IC50 of 0.027 μM over other phosphodiesterase enzymes, such as PDE1A, PDE2A and PDE3A. AN-2898 also potently inhibits PDE4 subtypes (PDE4B1, PDE4A1A and PDE4D2) . AN-2898 significantly inhibits the production of TNF-α, IL-2, IFN-γ, IL-5 and IL-10. AN-2898 can be used for mild to moderate atopic dermatitis (AD) and psoriasis research[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H301-H311-H331

• Target :

  IFNAR; Interleukin Related; Phosphodiesterase (PDE) ; TNF Receptor

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology

• Smiles :

  N#CC1=CC=C(OC2=CC=C(B(O)OC3)C3=C2)C=C1C#N

• Molecular Formula :

  C15H9BN2O3

• Molecular Weight :

  276.05

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

• References & Citations :

  [1]Freund YR, et al. Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center. FEBS Lett. 2012 Sep 21;586 (19) :3410-4.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  IL-10; IL-2; IL-5; PDE1; PDE2; PDE3; PDE4; PDE7

• CAS Number :

  [906673-33-4]