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AN-2898

CAT: 0804-HY-111167Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111167Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AN-2898 is a selective PDE4 inhibitor with IC50 of 0.027 μM over other phosphodiesterase enzymes, such as PDE1A, PDE2A and PDE3A. AN-2898 also potently inhibits PDE4 subtypes (PDE4B1, PDE4A1A and PDE4D2) . AN-2898 significantly inhibits the production of TNF-α, IL-2, IFN-γ, IL-5 and IL-10. AN-2898 can be used for mild to moderate atopic dermatitis (AD) and psoriasis research[1].
CAS Number
906673-33-4
UNSPSC
12352005
Hazard Statement
H301-H311-H331
Target
IFNAR; Interleukin Related; Phosphodiesterase (PDE) ; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
N#CC1=CC=C(OC2=CC=C(B(O)OC3)C3=C2)C=C1C#N
Molecular Formula
C15H9BN2O3
Molecular Weight
276.05
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
References & Citations
[1]Freund YR, et al. Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center. FEBS Lett. 2012 Sep 21;586 (19) :3410-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
IL-10; IL-2; IL-5; PDE1; PDE2; PDE3; PDE4; PDE7

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