Suc-YVAD-pNA

CAT: 0804-HY-P2630Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-P2630Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Suc-YVAD-pNA is a substrate of ICE. Interleukin-1β-converting enzyme (ICE) is a cysteine protease responsible for the cleavage of pre-interleukin-1β (pre-IL-1β) to the mature cytokine and a member of a family of related proteases (the caspases) [1].

CAS Number

208264-84-0

UNSPSC

12352209

Target

Interleukin Related

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/suc-yvad-pna.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@H](NC(CCC(O)=O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(NC2=CC=C(C=C2)[N+]([O-])=O)=O)=O)=O)=O

Molecular Formula

C31H38N6O12

Molecular Weight

686.67

References & Citations

[1]N Margolin, et al. Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases. J Biol Chem. 1997 Mar 14;272 (11) :7223-8.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Chemical Information

Suc-tyr-val-ala-asp-pna

CAS Number	208264-84-0
PubChem CID	90471008
IUPAC Name	(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-(3-carboxypropanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-(4-nitroanilino)-4-oxobutanoic acid
Molecular Formula	C31H38N6O12
Molecular Weight	686.7
XLogP	0.7
Topological Polar Surface Area	286
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	17
Heavy Atom Count	49
Formal Charge	0
Complexity	1210

SMILES

C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)CCC(=O)O

InChI

InChI=1S/C31H38N6O12/c1-16(2)27(36-30(46)22(34-24(39)12-13-25(40)41)14-18-4-10-21(38)11-5-18)31(47)32-17(3)28(44)35-23(15-26(42)43)29(45)33-19-6-8-20(9-7-19)37(48)49/h4-11,16-17,22-23,27,38H,12-15H2,1-3H3,(H,32,47)(H,33,45)(H,34,39)(H,35,44)(H,36,46)(H,40,41)(H,42,43)/t17-,22-,23-,27-/m0/s1

InChIKey

APPSYVHVOCTIDH-ZBBFOALVSA-N

Chemical Structure

2D Structure

CAS: 208264-84-0

CID: 90471008

Formula: C31H38N6O12

MW: 686.7

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	686.7
XLogP3	0.7
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	17
Exact Mass	686.25477067
Monoisotopic Mass	686.25477067
Topological Polar Surface Area	286 Å²
Heavy Atom Count	49
Formal Charge	0
Complexity	1210
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-P10317	Suc-YVAD-AMC
HY-P5974	Z-YVAD-pNA
HY-P2091-01	Ac-YVAD-pNA
HY-P2573-01	Suc-AAPF-pNA
HY-P4482-01	Suc-AAPE-pNA
HY-P4476-01	Suc-AAPA-pNA
HY-P4484-01	Suc-AAPK-pNA
HY-P4477	Suc-AAPR-pNA
HY-P4489	Suc-AAPM-pNA
HY-137409-01	Suc-AAA-pNA

Alternative Products

Catalog	Name
574010	Suc-YVAD-pNA
GTR19288623-01	Suc-YVAD-AMC
A8755-5	Ac-YVAD-pNA
ALX-260-049-M001	Z-YVAD-pNA
GTR19191481	Suc-YVAD-AMC (acetate)
L-1420.0005	Suc-Phe-pNA
MBS8247078-01	Suc-APA-pNA
CCP1440-01	Suc-LEPF-pNA

Suc-YVAD-pNA

Chemical Information

Related Products

Alternative Products

Popular Products